658460

AG 879 - CAS 148741-30-4 - Calbiochem

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation.

• 別名: AG 879 - CAS 148741-30-4 - Calbiochem, α-Cyano-(3,5-di- t-butyl-4-hydroxy)thiocinnamide
• 実験式（ヒル表記法）: C₁₈H₂₄N₂OS
• CAS番号: 148741-30-4
• 分子量: 316.46
• MDL番号: MFCD00236450
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange-yellow
• 溶解性: DMSO: 100 mg/mL; acetic acid: soluble; methanol: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
• InChI Key: LCUMYVYIHXYBIA-FOWTUZBSSA-N

詳細

詳細

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC₅₀ = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.

生物化学的／生理学的作用

Cell permeable: yes

EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation

Primary Target
(NGF)-dependent p140c-trk tyrosine phosphorylation

Product does not compete with ATP.

Reversible: yes

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Solubility- removed acetic acid, MeOH

その他情報

Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10-13 - German Storage Class 10 to 13