567305

SKF-86002

A cell-permeable, reversible, and ATP-competitive cytokine-suppressive anti-inflammatory drug (CSAID).

• 別名: SKF-86002, 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole
• 実験式（ヒル表記法）: C₁₆H₁₂FN₃S
• CAS番号: 72873-74-6
• 分子量: 297.35
• MDL番号: MFCD00869367
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
• InChI Key: YOELZIQOLWZLQC-UHFFFAOYSA-N

詳細

詳細

A cell-permeable, reversible, and ATP-competitive cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC₅₀ = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.

A cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC₅₀ = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
(LPS)-stimulated IL-1 and TNF-α production

Product competes with ATP.

Reversible: yes

Target IC₅₀: 1 µM inhibiting lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production

警告

Toxicity: Irritant (B)

その他情報

Frasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389.
Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63.
Lee, J.C., et al. 1995. Nature 372, 739.
Prichett, W., et al. 1995. J. Inflamm. 45, 97.
Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable