565792-M

γ-Secretase Inhibitor XXIII, Aβ42-Selective

The γ-Secretase Inhibitor XXIII, Aβ42-Selective controls the biological activity of γ-Secretase.

• 別名: γ-Secretase Inhibitor XXIII, Aβ42-Selective
• 実験式（ヒル表記法）: C₃₀H₃₉N₇O
• 分子量: 513.68
• UNSPSCコード: 12352203

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: beige
• 溶解性: DMSO: 25 mg/mL
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC₅₀ = 21 and 350 nM, respectively) and Notch1 (Notch IC₅₀/ Aβ42 IC₅₀ >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

その他情報

Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett.20, 2279.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable