529605-M

PP1 Analog

InSolution, ≥97%, ATP-competitive, inhibitor of Src-family tyrosine kinases

• 別名: InSolution PP1 Analog
• 実験式（ヒル表記法）: C₁₉H₁₉N₅
• CAS番号: 221243-82-9
• 分子量: 317.39
• UNSPSCコード: 12352200

特性

• アッセイ: ≥97% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 保管温度: −70°C
• InChI: 1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
• InChI Key: XSHQBIXMLULFEV-UHFFFAOYSA-N

詳細

詳細

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

再構成

Following initial thaw, aliquot and freeze (-70°C).

その他情報

Bishop, A.C., et al. 2000. Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.

法的情報

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)