5.05984

Mitochondrial Content Inducer, BRD6897

• 別名: Mitochondrial Content Inducer, BRD6897, BRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one
• 実験式（ヒル表記法）: C₂₅H₂₁N₃O₂S₂
• CAS番号: 618395-82-7
• 分子量: 459.58
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 10 mg/mL
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (~10 µM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (~50% increase in 3T3-L1 and HUVEC at 10 µM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.

生物化学的／生理学的作用

Cell permeable: yes

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Kitami, T., et al. 2012. PLoS ONE7, e33755.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable