5.04479

JNJ 16259685 - CAS 409345-29-5 - Calbiochem

• 別名: JNJ 16259685 - CAS 409345-29-5 - Calbiochem, (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
• 実験式（ヒル表記法）: C₂₀H₂₃NO₃
• CAS番号: 409345-29-5
• 分子量: 325.40
• UNSPSCコード: 12352200

特性

• アッセイ: ≥98% (TLC)
• 品質水準: 100
• フォーム: solid
• 有効性: 0.55 nM IC₅₀; 0.34 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white to off-white
• 溶解性: DMSO: 25 mM
• 保管温度: 2-8°C

詳細

詳細

An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (K_i = 0.34 nM; IC₅₀ = 0.55 nM). 400-fold more selective for mGlu₁ than for mGlu₅ and no interaction with mGlu₂, mGlu₃, mGlu₄, mGlu₆, AMPA or NMDA receptors (IC₅₀ >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.

生物化学的／生理学的作用

Primary Target
mGlu₁

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Lavreysen, H., et al. 2004. Neuropharmacology.47, 961.

Steckler, T., et al. 2005. Psychopharmacology.179, 198.

Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.

Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.

Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.

Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany