454862

MNK1/2 Inhibitor II, ETP-45835

The MNK1/2 Inhibitor II, ETP-45835 controls the biological activity of MNK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: MNK1/2 Inhibitor II, ETP-45835, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl, ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl
• 実験式（ヒル表記法）: C₁₃H₁₆N₄ · 2HCl
• CAS番号: 2136571-30-5
• 分子量: 301.21
• MDL番号: MFCD27919983
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: water: 50 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: C1(C2=CC=NC=C2)=CC(C3CCNCC3)=NN1

詳細

詳細

A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC₅₀ = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (≤15% inhibition at 5 µM). Reported to exhibit good aqueous solubility (>100 µM at pH 7.4) and inhibit the proliferation (IC₅₀ = 17 µM) and cellular eIF4E Ser²⁰⁹ phosphorylation (IC₅₀ = 4.7 µM) of MV4:11 cells.

A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC₅₀ = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against a panel of 24 other kinases (≤15% inhibition at 5 µM), including MNK upstream kinases B-Raf, ERK1, MEK1, and p38α. Reported to exhibit good aqueous solubility (>100 µM at pH 7.4) and inhibit the proliferation (IC₅₀ = 17 µM) and cellular eIF4E Ser²⁰⁹ phosphorylation (IC₅₀ = 4.7 µM) of acute myeloid leukemia MV4:11 cells.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Oyarzabal, J., et al. 2010. J. Med. Chem.53, 6618.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable