詳細
This product has been discontinued.
A selective, active site-directed, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2) but not of secretory PLA2.
A selective, active site-directed, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2) but not secretory PLA2.
生物化学的/生理学的作用
Cell permeable: no
Primary Target
calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2)
calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2)
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
物理的形状
In methyl acetate.
再構成
Prior to use, evaporate the methyl acetate and resuspend in high quality chloroform. Aliquot and immediately evaporate the chloroform. Store aliquots at -70°C. Reconstitute in DMSO just prior to use.
その他情報
Balsinde, J., and Dennis, E.A. 1996. J. Biol. Chem. 271, 6758.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta1302, 55.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta1302, 55.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
The Journal of biological chemistry, 271(12), 6758-6765 (1996-03-22)
Receptor-stimulated arachidonic acid (AA) mobilization in P388D1 macrophages consists of a transient phase in which AA accumulates in the cell and a sustained phase in which AA accumulates in the incubation medium. We have shown previously that a secretory group
Biochimica et biophysica acta, 1302(1), 55-60 (1996-07-12)
Methyl arachidonyl fluorophosphonate (MAFP) has been recently reported to be a selective, active-site directed, irreversible inhibitor of the Group IV 85 kDa cytosolic phospholipase A2 (cPLA2). We have now shown that this compound also potently inhibits the Ca(2+)-independent cytosolic phospholipase
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