444247

MMP Inhibitor II

The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: MMP Inhibitor II, N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
• 実験式（ヒル表記法）: C₂₁H₂₇N₃O₈S₂
• CAS番号: 203915-59-7
• 分子量: 513.58
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: off-white
• 溶解性: DMSO: 100 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C21H27N3O8S2/c1-21(2)13-23(33(27,28)17-9-5-15(31-3)6-10-17)20(19(25)22-26)24(14-21)34(29,30)18-11-7-16(32-4)8-12-18/h5-12,20,26H,13-14H2,1-4H3,(H,22,25)
• InChI Key: MCSWSPNUKWMZHM-UHFFFAOYSA-N

詳細

詳細

A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

A potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

生物化学的／生理学的作用

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

調製ノート

Requires vigorous vortexing for 60 seconds to completely solubilize the product.

その他情報

Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable