371709

GPR109b Agonist - CAS 306935-41-1 - Calbiochem

The GPR109b Agonist, also referenced under CAS 306935-41-1, controls the biological activity of GPR109b. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

• 別名: GPR109b Agonist - CAS 306935-41-1 - Calbiochem, 1-( iso-Propyl)-1H-benzotriazole-5-carboxylic acid, 1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid
• 実験式（ヒル表記法）: C₁₀H₁₁N₃O₂
• CAS番号: 306935-41-1
• 分子量: 205.21
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: light brown
• 溶解性: ethanol: 2 mg/mL; DMSO: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable Niacin (Cat. No. 481918) triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or β-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5 µM, Cat. No. 344270) and isoproterenol (1 µM, Cat. No. 420355), respectively, in GPR109b-expressing CHO cells (EC₅₀ = 400 nM) and freshly isolated human adipocytes (EC₅₀ about 1 µM).

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Semple, G., et al. 2006. J. Med. Chem.49, 1227.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable