371545

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.

• 別名: Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem, GTPγ-S, 4Li
• 実験式（ヒル表記法）: C₁₀H₁₂N₅O₁₃P₃S · 4Li
• CAS番号: 94825-44-2
• 分子量: 562.98
• MDL番号: MFCD00135151
• UNSPSCコード: 12352200

特性

• アッセイ: ≥85% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 不純物: ≤12% GDP
• 色: white
• 溶解性: water: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

G-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P₃ formation in membranes.

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
G-protein-activating GTP analog

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.

その他情報

Iino, S., et al. 2000. FEBS Lett.479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem.267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci.49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol.422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Orellana, S., et al. 1987. J. Biol. Chem..262, 1638.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable