219674

CFTR Inhibitor-172

InSolution, ≥95%

• 別名: InSolution CFTR Inhibitor-172, (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTR_inh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone, (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTR_inh-172 in DMSO
• 実験式（ヒル表記法）: C₁₈H₁₀F₃NO₃S₂
• CAS番号: 307510-92-5
• 分子量: 409.40
• MDL番号: MFCD06411408
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 輸送温度: dry ice
• 保管温度: −70°C
• InChI: 1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-
• InChI Key: JIMHYXZZCWVCMI-ZSOIEALJSA-N

詳細

詳細

A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl^- transport in human airway cells (K_i ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl^- channels, MDR-1, ATP-sensitive K⁺ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
CFTR ion-channel

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.

再構成

Following initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.

その他情報

Yang, H., et al. 2003. J. Biol. Chem.278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest.110, 1599.
Ma, T., et al. 2002. J. Clin. Invest.110, 1651.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): 188.6 °F - closed cup - (refers to pure substance)
• 引火点(℃): 87 °C - closed cup - (refers to pure substance)