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資料

試験成績書（COA）/品質証明書（COQ）

14-329-M

JNK2α2/SAPK1a Protein, active, 10 µg

Name: JNK2α2/SAPK1a Protein, active, 10 µg
Brand: MM

Active, N-terminal His-tagged, full length human JNK2α2/SAPK1a, for use in Kinase Assays.

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About This Item

UNSPSCコード:

12352202

eCl@ss:

32160405

NACRES:

NA.41

由来生物

human

品質水準

100

分子量

M_w 49.2 kDa

メーカー／製品名

Upstate^®

テクニック

activity assay: suitable (kinase)

詳細

N-terminal His-tagged, full length human JNK2α2/SAPK1a

Product Source: Expressed in Sf21 cells

生物化学的／生理学的作用

Protein Target: JNK2α2/SAPK1a

Target Sub-Family: CMGC

包装

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-329M when ordering the 250 µg size.

品質

Routinely evaluated by phosphorylation of ATF2 (amino acids 19-96)

物理的形状

Ni²⁺/NTA-agarose

保管および安定性

6 months at -70°C

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

試験成績書（COA）

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JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis.

Girish V Putcha et al.

Neuron, 38(6), 899-914 (2003-06-24)

Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

Y Zhang et al.

The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)

Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well

Transcription factor ATF2 regulation by the JNK signal transduction pathway.

S Gupta et al.

Science (New York, N.Y.), 267(5196), 389-393 (1995-01-20)

Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating transcription factor-2 (ATF2) was found to be a target of the JNK signal transduction pathway. ATF2 was phosphorylated by JNK on

Selective interaction of JNK protein kinase isoforms with transcription factors.

S Gupta et al.

The EMBO journal, 15(11), 2760-2770 (1996-06-03)

The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and tyrosine. Ten JNK isoforms were identified in human brain by molecular cloning. These protein kinases correspond to

ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10.

S P Zhong et al.

The Journal of biological chemistry, 275(28), 20980-20984 (2000-05-12)

Histone H3 is the core protein of the nucleosome. Phosphorylation of H3 involves immediate early gene expression, chromatin remodeling, and chromosome condensation during mitosis. Very recently, Rsk2 or MSK1 kinase-mediated phosphorylation of H3 at serine 10 was reported. In the

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