由来生物
rabbit
抗体製品の状態
serum
抗体製品タイプ
primary antibodies
クローン
polyclonal
化学種の反応性
human
化学種の反応性（ホモロジーによる予測）
mouse (based on 100% sequence homology)
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CHD4(1108)
詳細
CHD-4 is also often referred to as Mi2-beta. This protein is a central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. CHD4 has been shown to interact with TRIM27, HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related. This protein also interacts with KLF1. This interaction which depends on sumoylation of KLF1 leads to its transcriptional repression.
特異性
Rat (96%).
This antibody recognizes CHD-4 at the N-terminus.
免疫原
Epitope: N-terminus
GST-tagged recombinant protein corresponding to mouse CHD-4 at and around the N-terminus.
アプリケーション
Research Category
エピジェネティクス及び核内機能分子
エピジェネティクス及び核内機能分子
Research Sub Category
エピジェネティクス
エピジェネティクス
Use Anti-Mi-2b (CHD4) Antibody (rabbit polyclonal antibody) validated in WB to detect Mi-2b (CHD4) also known as ATP-dependent helicase CHD4, Mi-2 autoantigen 218 kDa protein, chromodomain helicase DNA binding protein 4.
品質
Evaluated by Western Blot in HeLa nuclear extract cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected CHD-4 on 10 µg of HeLa nuclear extract cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected CHD-4 on 10 µg of HeLa nuclear extract cell lysate.
ターゲットの説明
217 kDa
物理的形状
Unpurified
Unpurified rabbit polyclonal in serum with 0.05% sodium azide.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
アナリシスノート
Control
HeLa nuclear extract cell lysate
HeLa nuclear extract cell lysate
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
06-1306:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Xiaofei Yu et al.
Haematologica, 104(12), 2361-2371 (2019-04-21)
As high fetal hemoglobin levels ameliorate the underlying pathophysiological defects in sickle cell anemia and beta (β)-thalassemia, understanding the mechanisms that enforce silencing of fetal hemoglobin postnatally offers the promise of effective molecular therapy. Depletion of the Nucleosome Remodeling and
Mario Torrado et al.
The FEBS journal, 284(24), 4216-4232 (2017-10-25)
The nucleosome remodelling and deacetylase (NuRD) complex is essential for the development of complex animals. NuRD has roles in regulating gene expression and repairing damaged DNA. The complex comprises at least six proteins with two or more paralogues of each
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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