PSMC1
proteasome (prosome, macropain) 26S subunit, ATPase, 1
別名:
P26S4, S4, p56
Species:
Human PSMC1 (5700), Mouse Psmc1 (19179), Rat Psmc1 (117263), Horse PSMC1 (100062573), chicken PSMC1 (395804), domestic guinea pig Psmc1 (100733985), naked mole-rat Psmc1 (101698658), sheep PSMC1 (101120165), domestic cat PSMC1 (101094025), cow PSMC1 (506238)
UniProtKB ID:
遺伝子ID:
- Human(5700) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
- Mouse(19179) protease (prosome, macropain) 26S subunit, ATPase 1
- Rat(117263) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- Horse(100062573) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- chicken(395804) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- domestic guinea pig(100733985) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- naked mole-rat(101698658) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- sheep(101120165) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- domestic cat(101094025) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- cow(506238) proteasome (prosome, macropain) 26S subunit, ATPase, 1
- dog(100688636) proteasome (prosome, macropain) 26S subunit, ATPase, 1
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗PSMC1抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human, mouse, rat
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PSMC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
抗PSMC1抗体 ウサギ宿主抗体, affinity isolated antibody,
交差性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
アプリケーション
western blot
Small Molecule - Inhibitor
製品番号
詳細
Species
esiRNA
製品番号
詳細
Species