コンテンツへスキップ
Merck

NR1H3

nuclear receptor subfamily 1, group H, member 3

別名:
LXR-a, LXRA, RLD-1
Species:
UniProtKB ID:
遺伝子ID:
  • Human(10062) Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Mouse(22259) nuclear receptor subfamily 1, group H, member 3
  • Rat(58852) nuclear receptor subfamily 1, group H, member 3
  • chicken(395221) nuclear receptor subfamily 1, group H, member 3
  • Zebrafish(548341) nuclear receptor subfamily 1, group H, member 3
  • naked mole-rat(101709627) nuclear receptor subfamily 1, group H, member 3
  • domestic guinea pig(100725013) nuclear receptor subfamily 1, group H, member 3
  • Goat(100860906) nuclear receptor subfamily 1, group H, member 3
  • sheep(101116762) nuclear receptor subfamily 1, group H, member 3
  • cow(507176) nuclear receptor subfamily 1, group H, member 3
  • domestic cat(101092889) nuclear receptor subfamily 1, group H, member 3
  • dog(483625) nuclear receptor subfamily 1, group H, member 3

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

製品番号
詳細
Species
ヒオデオキシコール酸, ≥98%,
Species
human
T0901317, ≥98%,
Species
human

Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-LXR-A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
交差性
human, mouse, rat
アプリケーション
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-LXR alpha Antibody, clone 2B7, clone 2B7, from mouse,
交差性
mouse, rat
アプリケーション
immunoprecipitation (IP)
western blot
抗NR1H3抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
western blot
抗NR1H3抗体 ウサギ宿主抗体, IgG fraction of antiserum,
交差性
human
アプリケーション
western blot
Anti-LXRα antibody produced in rabbit, ,
交差性
mouse, rat
アプリケーション
immunohistochemistry
western blot

Small Molecule - Mixed Agonist/Antagonist

製品番号
詳細
Species
T0901317, ≥98%,
Species
human

Proteins

製品番号
詳細
Species
LXRα-リガンド結合ドメイン (215-667) ヒト, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
LXR, α、リガンド結合ドメイン、GSTタグ融合 ヒト, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human
LXR, α 異性体、 GSTタグ融合 ヒト, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
LXR, α 異性体、N末端領域 (1-182)、GSTタグ融合 β ヒト, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting mouse Nr1h3,
Species
mouse
MISSION® esiRNA, targeting human NR1H3,
Species
human