NISCH
nischarin
別名:
I-1, IR1, IRAS, hIRAS
Species:
Human NISCH (11188), Mouse Nisch (64652), Rat Nisch (306255), Zebrafish nisch (553087), chicken NISCH (415893), domestic cat NISCH (101083249), dog NISCH (476594), sheep NISCH (101111584), domestic guinea pig Nisch (100730252), cow NISCH (515009) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(11188) Summary: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
- Mouse(64652) nischarin
- Rat(306255) nischarin
- Zebrafish(553087) nischarin
- chicken(415893) nischarin
- domestic cat(101083249) nischarin
- dog(476594) nischarin
- sheep(101111584) nischarin
- domestic guinea pig(100730252) nischarin
- cow(515009) nischarin
- Horse(100060179) nischarin
- Domestic Rabbit(100346537) nischarin
- naked mole-rat(101701602) nischarin
- cow(100336473) nischarin
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Small Molecule - Agonist
Antibodies
製品番号
詳細
交差性
アプリケーション
Anti-NISCH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Monoclonal Anti-NISCH antibody produced in mouse, clone 2C8, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
western blot
western blot
Monoclonal Anti-NISCH antibody produced in mouse, clone 3B8, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
western blot
western blot