KMT2A
lysine (K)-specific methyltransferase 2A
別名:
ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS
Species:
Human KMT2A (4297), Mouse Kmt2a (214162), Rat Kmt2a (315606), cow KMT2A (508330), naked mole-rat Kmt2a (101716671), domestic guinea pig Kmt2a (100727230), Zebrafish kmt2a (557048)
UniProtKB ID:
遺伝子ID:
- Human(4297) Summary: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
- Mouse(214162) lysine (K)-specific methyltransferase 2A
- Rat(315606) lysine (K)-specific methyltransferase 2A
- cow(508330) lysine (K)-specific methyltransferase 2A
- naked mole-rat(101716671) lysine (K)-specific methyltransferase 2A
- domestic guinea pig(100727230) lysine (K)-specific methyltransferase 2A
- Zebrafish(557048) lysine (K)-specific methyltransferase 2A
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Antibodies
製品番号
詳細
交差性
アプリケーション
Anti-MLL/HRX Antibody, CT., clone 9-12, clone 9-12, Upstate®, from mouse,
交差性
human, mouse
アプリケーション
ChIP
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Anti-Acetyl MLL1 (KMT2A) (Lys 1130/1133), from rabbit,
交差性
human, mouse
アプリケーション
dot blot
inhibition assay
western blot
inhibition assay
western blot
Anti-MLL/HRX Antibody, NT., clone N4.4, clone N4.4, Upstate®, from mouse,
交差性
human, mouse
アプリケーション
immunoprecipitation (IP)
western blot
western blot
Anti-KMT2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
交差性
human
アプリケーション
immunofluorescence
esiRNA
製品番号
詳細
Species