FXYD5
FXYD domain containing ion transport regulator 5
別名:
DYSAD, IWU1, KCT1, OIT2, PRO6241, RIC
Species:
Human FXYD5 (53827), Mouse Fxyd5 (18301), Rat Fxyd5 (60338), naked mole-rat Fxyd5 (101707412), cow FXYD5 (505584), sheep FXYD5 (101105940), domestic guinea pig Fxyd5 (100719588), dog FXYD5 (612666)
UniProtKB ID:
遺伝子ID:
- Human(53827) Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
- Mouse(18301) FXYD domain-containing ion transport regulator 5
- Rat(60338) FXYD domain-containing ion transport regulator 5
- naked mole-rat(101707412) FXYD domain containing ion transport regulator 5
- cow(505584) FXYD domain containing ion transport regulator 5
- sheep(101105940) FXYD domain containing ion transport regulator 5
- domestic guinea pig(100719588) FXYD domain containing ion transport regulator 5
- dog(612666) FXYD domain containing ion transport regulator 5
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗FXYD5抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Fxyd5 Antibody Produced In Mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL14039, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Monoclonal Anti-Fxyd5 Antibody Produced In Mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL14037, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
抗ディスアドヘリン抗体 ヤギ宿主抗体, affinity isolated antibody, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
western blot
western blot