F13A1
coagulation factor XIII, A1 polypeptide
別名:
F13A
Species:
Human F13A1 (2162), Mouse F13a1 (74145), Rat F13a1 (60327), naked mole-rat F13a1 (101715346), chicken F13A1 (395420), dog F13A1 (478711), domestic cat F13A1 (101080534), Horse F13A1 (100060428), cow F13A1 (617881), sheep F13A1 (101108612)
UniProtKB ID:
遺伝子ID:
- Human(2162) Summary: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
- Mouse(74145) coagulation factor XIII, A1 subunit
- Rat(60327) coagulation factor XIII, A1 polypeptide
- naked mole-rat(101715346) coagulation factor XIII, A1 polypeptide
- chicken(395420) coagulation factor XIII, A1 polypeptide
- dog(478711) coagulation factor XIII, A1 polypeptide
- domestic cat(101080534) coagulation factor XIII, A1 polypeptide
- Horse(100060428) coagulation factor XIII, A1 polypeptide
- cow(617881) coagulation factor XIII, A1 polypeptide
- sheep(101108612) coagulation factor XIII, A1 polypeptide
- domestic guinea pig(100719684) coagulation factor XIII, A1 polypeptide
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗F13A1抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Monoclonal Anti-F13A1 antibody produced in mouse, clone 4G5, ascites fluid,
交差性
human
アプリケーション
ELISA
western blot
western blot
Monoclonal Anti-F13A1 antibody produced in mouse, clone M1, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
proximity ligation assay
proximity ligation assay
抗F13A1抗体 ウサギ宿主抗体, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
western blot