DLAT
dihydrolipoamide S-acetyltransferase
別名:
DLTA, PDC-E2, PDCE2
Species:
Human DLAT (1737), Mouse Dlat (235339), Rat Dlat (81654), chicken DLAT (419796), Zebrafish dlat (324201), domestic guinea pig Dlat (100735563), dog DLAT (489406), sheep DLAT (101110965), cow DLAT (512723), Horse DLAT (100062027) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(1737) Summary: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
- Mouse(235339) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
- Rat(81654) dihydrolipoamide S-acetyltransferase
- chicken(419796) dihydrolipoamide S-acetyltransferase
- Zebrafish(324201) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
- domestic guinea pig(100735563) dihydrolipoamide S-acetyltransferase
- dog(489406) dihydrolipoamide S-acetyltransferase
- sheep(101110965) dihydrolipoamide S-acetyltransferase
- cow(512723) dihydrolipoamide S-acetyltransferase
- Horse(100062027) dihydrolipoamide S-acetyltransferase
- domestic cat(101094126) dihydrolipoamide S-acetyltransferase
- Domestic Rabbit(100349212) dihydrolipoamide S-acetyltransferase
- naked mole-rat(101698667) dihydrolipoamide S-acetyltransferase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
製品番号
詳細
交差性
アプリケーション
抗DLAT抗体 ウサギ宿主抗体, IgG fraction of antiserum,
交差性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
アプリケーション
immunohistochemistry
western blot
western blot
抗DLAT抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DLAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
交差性
human
アプリケーション
immunofluorescence
western blot
western blot
抗DLAT抗体 ウサギ宿主抗体, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
immunofluorescence
western blot
western blot
esiRNA
製品番号
詳細
Species