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Merck

COMT

catechol-O-methyltransferase

別名:
Species:
UniProtKB ID:
遺伝子ID:
  • Human(1312) Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
  • Mouse(12846) catechol-O-methyltransferase
  • Rat(24267) catechol-O-methyltransferase
  • cow(618278) catechol-O-methyltransferase
  • domestic guinea pig(100730509) catechol-O-methyltransferase
  • domestic cat(101097022) catechol-O-methyltransferase
  • naked mole-rat(101717730) catechol-O-methyltransferase
  • chicken(416783) catechol-O-methyltransferase
  • Horse(100146509) catechol-O-methyltransferase
  • fruit fly(47091) comatose
  • dog(445450) catechol-O-methyltransferase

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Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-Catechol O-methyltransferase/COMT Antibody, from rabbit, purified by affinity chromatography,
交差性
bovine, horse, human, porcine, rhesus macaque
アプリケーション
immunohistochemistry
western blot
抗COMT ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human, rat
アプリケーション
western blot
抗COMT抗体 ウサギ宿主抗体, affinity isolated antibody,
交差性
human
アプリケーション
ELISA
western blot
Monoclonal Anti-COMT antibody produced in mouse, clone 1G4-1A1, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
western blot
抗COMT抗体 マウス宿主抗体, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
トルカポン, ≥98% (HPLC),
Species
human
トルカポン, United States Pharmacopeia (USP) Reference Standard,
Species
human
Ro 41-0960, solid,
Species
human
3,5-Dinitrocatechol, solid,
Species
human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human COMT,
Species
human