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1359903

USP

Levocarnitine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

L-Carnitine inner salt, (−)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate, Vitamin BT

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About This Item

Linear Formula:
(CH3)3N+CH2CH(OH)CH2COO-
CAS Number:
541-15-1
Molecular Weight:
161.20
Beilstein:
4292315
MDL number:
MFCD00038747
UNSPSC Code:
41116107
PubChem Substance ID:
329750039
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

levocarnitine

manufacturer/tradename

USP

mp

197-212 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[N+](C)(C)C[C@H](O)CC([O-])=O

InChI

1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1

InChI key

PHIQHXFUZVPYII-ZCFIWIBFSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Levocarnitine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Levocarnitine Tablets
  • Levocarnitine Injection
  • Levocarnitine Oral Solution

Biochem/physiol Actions

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

1359903-400MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P D Pion et al.
The Veterinary clinics of North America. Small animal practice, 28(6), 1495-1514 (1999-03-31)
In this article, the current state of knowledge of the potential role of taurine and L-carnitine deficiency and supplementation in the genesis and management of cardiovascular disease in dogs is presented. There is limited direct evidence to support the recommendations
Allan Evans
American journal of kidney diseases : the official journal of the National Kidney Foundation, 41(4 Suppl 4), S13-S26 (2003-05-17)
Among the homeostatic processes controlling the endogenous L-carnitine pool in humans, the kidney has a vital role through extensive and adaptive tubular reabsorption. Kidney disease can lead to disturbances in L-carnitine homeostasis, and long-term hemodialysis therapy can lead to a
Yasuro Furuichi et al.
Biochimica et biophysica acta, 1837(10), 1699-1706 (2014-06-03)
Carnitine is well recognized as a key regulator of long-chain fatty acyl group translocation into the mitochondria. In addition, carnitine, as acetylcarnitine, acts as an acceptor of excess acetyl-CoA, a potent inhibitor of pyruvate dehydrogenase. Here, we provide a new
Marieke G Schooneman et al.
Biochimica et biophysica acta, 1841(7), 987-994 (2014-04-22)
Acylcarnitines have been linked to obesity-induced insulin resistance. However the majority of these studies have focused on acylcarnitines in plasma. It is currently unclear to what extent plasma levels of acylcarnitines reflect tissue acylcarnitine metabolism. We investigated the correlation of
Reese H Clark et al.
Pediatrics, 134(1), e37-e46 (2014-06-11)
To describe the influence that gestational age and chronological age have on amino acid and acylcarnitine profiles in an at-risk population of premature infants. Metabolic profiles (15 amino acids and 35 acylcarnitines) were obtained by using standard newborn techniques on
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