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V7127

Sigma-Aldrich

D-Val-Leu-Lys p-nitroanilide dihydrochloride

plasmin substrate, chromogenic, ≥98% (HPLC), powder

Synonym(s):

D-Val-Leu-Lys p-nitroanilide

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About This Item

Empirical Formula (Hill Notation):
C23H38N6O5 · 2HCl
Molecular Weight:
551.51
UNSPSC Code:
12352204
PubChem Substance ID:
24900765
NACRES:
NA.32

product name

D-Val-Leu-Lys p-nitroanilide dihydrochloride, plasmin substrate

Assay

≥98% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, light yellow

storage temp.

−20°C

InChI

1S/C23H38N6O5.ClH/c1-14(2)13-19(28-23(32)20(25)15(3)4)22(31)27-18(7-5-6-12-24)21(30)26-16-8-10-17(11-9-16)29(33)34;/h8-11,14-15,18-20H,5-7,12-13,24-25H2,1-4H3,(H,26,30)(H,27,31)(H,28,32);1H

InChI key

ITWYYDDNWFVYSU-UHFFFAOYSA-N

Application

D-Val-Leu-Lys p-nitroanilide dihydrochloride has been used:
  • as substrate to measure the activity of plasminogen activator by a chromogenic assay
  • as a p-nitroanilide (pNA) substrate to measure the specific activities of serine protease isoforms in Gloydius intermedius venom
  • as a substrate in total plasmin assay using milk/cream samples

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

V7127-VAR:
V7127-100MG:
V7127-1MG:
V7127-25MG:
V7127-5MG:
V7127-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ezio Fasoli et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 930, 13-21 (2013-05-25)
Despite membrane-based separations offering superior alternative to packed bed chromatographic processes, there has been a substantial lacuna in their actual application to separation processes. One of the major reasons behind this is the lack of availability of appropriately modified or
Zhang-Min Yang et al.
Journal of proteomics, 164, 19-32 (2017-05-31)
Nine distinct venom serine proteases (vSPs) of Gloydius intermedius were studied by transcriptomic, sub-proteomic and phylogenetic analyses. Their complete amino acid sequences were deduced after Expression Sequence Tag (EST) analyses followed by cDNA cloning and sequencing. These vSPs appear to
S Vijayakumar et al.
Journal of dairy science, 98(10), 6678-6691 (2015-08-04)
The shelf life of pasteurized milk is limited by heat-stable proteases, which cause gelation and bitter taste upon extended storage of milk. Ultra-high temperature processing inactivates proteases but detrimentally affects milk's sensory quality. An adjunct to pasteurization is desired to
Role of lysine binding regions in the kinetic properties of human plasmin.
J P Morris et al.
Biochemistry, 20(17), 4811-4816 (1981-08-18)
A Santillo et al.
Journal of dairy science, 105(11), 8609-8620 (2022-09-30)
The aim of the present study was to assess the dietary supplementation of tannins to grazing dairy cows in 2 seasons characterized by a good quality pasture (spring) or a poor-quality pasture (summer). The effects of dietary tannins were assessed
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