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Safety Information

UC282

Sigma-Aldrich

6β-Hydroxytestosterone

≥97% (HPLC)

Synonym(s):

4-Androstene-6β,17β-diol-3-one, 6β, 17β,-Dihydroxyandrost-4-en-3-one

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About This Item

Empirical Formula (Hill Notation):
C19H28O3
CAS Number:
62-99-7
Molecular Weight:
304.42
MDL number:
MFCD00171612
UNSPSC Code:
12161501
PubChem Substance ID:
24900687

Assay

≥97% (HPLC)

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to off-white

mp

≥205 °C

solubility

acetonitrile: soluble
ethanol: soluble
methanol: soluble

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](C[C@@H](O)C4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1

InChI key

XSEGWEUVSZRCBC-ZVBLRVHNSA-N

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Application

6β-Hydroxytestosterone has been used for CYP3A activity assays in rat hepatocytes and has also been used for CYP3A4 substrate selection studies.

Biochem/physiol Actions

6β-Hydroxytestosterone is a CYP3A4 metabolite; androgenic.

Preparation Note

6β-Hydroxytestosterone is soluble in methanol, acetonitrile and ethanol.

replaced by

Product No.
Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360

Precautionary Statements

P201 - P281 - P308 + P313

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

UC282-BULK:
UC282-VAR:
UC282-5MG:
UC282-10MG:

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Certificates of Analysis (COA)

Lot/Batch Number
068K3351
037K3851

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Aleksandra Galetin et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 180-190 (2005-03-24)
The complexity of in vitro kinetic phenomena observed for CYP3A4 substrates (homo- or heterotropic cooperativity) confounds the prediction of drug-drug interactions, and an evaluation of alternative and/or pragmatic approaches and substrates is needed. The current study focused on the utility
Yoshitaka Miyamoto et al.
Cell transplantation, 18(5), 677-681 (2009-09-25)
Three-dimensional culture procedures have attracted attention in various fields of cell biology. A newly developed cell array assisted in the formation of hepatocyte spheroids by two innovations: 1) micropatterning by a hydrophilic polymer, and 2) the use of bovine carotid
Dan A Rock et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2410-2413 (2008-09-04)
Cytochrome P450 (P450) reaction phenotyping is a key process toward accurately determining the contribution of different P450s to the metabolism of new chemical entities. The significance of P450s to drug disposition has led to the identification of selective chemical and
Cuiping Chen et al.
The Journal of pharmacology and experimental therapeutics, 300(2), 417-420 (2002-01-24)
The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine. However
Yong Liu et al.
Biological & pharmaceutical bulletin, 27(10), 1555-1560 (2004-10-07)
The intestinal bacterial metabolites of ginsenosides are responsible for the main pharmacological activities of ginseng. The purpose of this study was to find whether these metabolites influence hepatic metabolic enzymes and to predict the potential for ginseng-prescription drug interactions. Utilizing
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