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U9382

Sigma-Aldrich

Ubiquitin-Carrier Protein H10 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli (histidine-tagged), buffered aqueous glycerol solution

Synonym(s):

UbcH10

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About This Item

MDL number:
MFCD03458906
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in E. coli (histidine-tagged)

Assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~20 kDa

technique(s)

ligand binding assay: suitable

UniProt accession no.

O00762

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... UBE2C(11065)

General description

Manufactured for Sigma by Boston Biochem., Inc.

Application

Ubiquitin-Carrier Protein H10 (UbcH10) human may be used to study the role of ubiquitin-proteasome system in pathogenesis of human diseases.

Biochem/physiol Actions

In conjunction with the anaphase-promoting complex, the protein catalyzes the destruction of both cyclin A and cyclin B.
Ubiquitin-Carrier Protein H10 human also referred to as UbcH10 is a recombinant protein that catalyzes the destruction of cyclin A as well as cyclin B along with the anaphase promoting complex and hence plays a pivotal role in controlling the cell exit from mitosis.

Physical form

Solution in 50 mM HEPES, pH 8.0, 125 mM NaCl, and 1 mM DTT in 10% glycerol.

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

U9382-VAR:
U9382-100UG:
U9382-BULK:
U9382-100UG-PW:

Certificates of Analysis (COA)

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F M Townsley et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(6), 2362-2367 (1997-03-18)
Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to complete mitosis and enter interphase of the next cell cycle. In clam eggs, this process is catalyzed by a cyclin-selective ubiquitin carrier protein, E2-C, and the cyclosome/anaphase promoting

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