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Safety Information

U9132

Sigma-Aldrich

Ubiquitin-Carrier Protein H7 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, liquid

Synonym(s):

UbcH7

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About This Item

MDL number:
MFCD03458911
UNSPSC Code:
12352202
NACRES:
NA.56

recombinant

expressed in E. coli

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

liquid

mol wt

18 kDa

UniProt accession no.

P60604
P68036

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... UBE2G2(7327) , UBE2L3(7332)

General description

Manufactured for Sigma by Boston Biochem., Inc.

Biochem/physiol Actions

Acts in conjunction with Ubc6 to degrade MAT α2 factor.
May act in both the degradation of non-N-end rule protein substrates and of certain Nα-acetylated proteins as well as the degradation of tumor suppressor protein p53.

Physical form

Solution in 50 mM HEPES, pH 8.0, 50 mM NaCl, 1 mM DTT in 10% glycerol.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

U9132-100UG-PW:
U9132-BULK:
U9132-VAR:
U9132-100UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P Chen et al.
Cell, 74(2), 357-369 (1993-07-30)
Attachment of ubiquitin to proteins is catalyzed by a family of ubiquitin-conjugating (UBC) enzymes. Although these enzymes are essential for many cellular processes; their molecular functions remain unclear because no physiological target has been identified for any of them. Here
Jian Wang et al.
The Journal of biological chemistry, 285(16), 12279-12288 (2010-02-23)
Nedd4 E3 ligases are members of the HECT E3 ubiquitin ligase family and regulate ubiquitination-mediated protein degradation. In this report, we demonstrate that calcium releases the C2 domain-mediated auto-inhibition in both Nedd4-1 and Nedd4-2. Calcium disrupts binding of the C2
Evangelia Koutelou et al.
The Journal of biological chemistry, 283(7), 3846-3853 (2007-12-14)
Notch signaling constitutes an evolutionarily conserved mechanism that mediates cell-cell interactions in various developmental processes. Numerous regulatory proteins interact with the Notch receptor and its ligands and control signaling at multiple levels. Ubiquitination and endocytosis followed by endosomal sorting of

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