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Safety Information

T9177

Sigma-Aldrich

Tyrphostin AG 126

≥90%

Synonym(s):

(3-Hydroxy-4-nitrobenzylidene)malononitrile

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About This Item

Empirical Formula (Hill Notation):
C10H5N3O3
CAS Number:
118409-62-4
Molecular Weight:
215.17
MDL number:
MFCD00236448
UNSPSC Code:
12352200
PubChem Substance ID:
24278763

Assay

≥90%

storage temp.

−20°C

SMILES string

Oc1cc(ccc1[N+]([O-])=O)\C=C(\C#N)C#N

Gene Information

human ... TNF(7124)

Application

Tyrphostin AG 126 has been used in LOPAC screening assays to identify histone deacetylase (HDAC) inhibitors.

Biochem/physiol Actions

Tyrphostin AG 126 is a tyrosine kinase inhibitor that is known to block the production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in macrophages. Furthermore, studies have reported that AG 126 can reduce zymosan-induced multiple organ failure in rats, block the postoperative ileus development in mice, and also decrease colitis development in rats.

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

T9177-VAR:
T9177-25MG:4548173214467
T9177-5MG:4548173214474
T9177-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Oliver Kann et al.
Journal of neurochemistry, 90(3), 513-525 (2004-07-17)
We recently reported that lasting activation of mouse microglial cells with bacterial lipopolysaccharide (LPS) chronically elevated the basal intracellular calcium concentration ([Ca2+]i). This correlated to an attenuated calcium signaling of complement (C5a) and purinergic (UTP) receptors as well as to
Klemens Angstwurm et al.
Infection and immunity, 72(6), 3294-3298 (2004-05-25)
Bacterial meningitis is an acute inflammatory disease of the central nervous system with a mortality rate of up to 30%. Excessive stimulation of the host immune system by bacterial surface components contributes to this devastating outcome. In vitro studies have
Hua Yuan et al.
American journal of physiology. Heart and circulatory physiology, 296(2), H470-H479 (2008-12-23)
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial depression that is a common feature of endotoxemia in patients. In this setting the myocardial dysfunction appears to be due
M G Rittig et al.
Cellular microbiology, 5(12), 887-899 (2003-12-04)
Following reports that a VacA+cag+ toxigenic but not a VacA-cag- non-toxigenic Helicobacter pylori strain induced homotypic phagosome fusion in murine macrophages, we addressed that phenomenon in human cells. Mononuclear phagocytes and epitheloid cells were challenged with H. pylori strains of
Yun Jeong Kim et al.
Neurochemical research, 35(4), 603-612 (2009-12-04)
The preventive effect of tyrosine kinase inhibitor AG126 against the 7-ketocholesterol toxicity was investigated in relation to the mitochondria-mediated cell death process. 7-Ketocholesterol induced the nuclear damage, the mitochondrial membrane permeability changes, the formation of reactive oxygen species and the
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