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SRP6595

Sigma-Aldrich

IL-22 human

recombinant, expressed in HEK 293 cells (Ala 34 - Ile 179), ≥95% (SDS-PAGE)

Synonym(s):

IL-TIF, ZCYTO18

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells (Ala 34 - Ile 179)

tag

His tagged

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 17.6 kDa (a polyhistidine tag at the N-terminus.)
observed mol wt 21-33 kDa (DTT-reduced protein.Protein migrates as 21-33 kDa in a SDS-PAGE due to glycosylation.
)

packaging

pkg of 10 μg

impurities

<1 EU/μg (LAL test)

UniProt accession no.

Q9GZX6

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL22(50616)

General description

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP6595-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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