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Safety Information

SRP6251

Sigma-Aldrich

CCL6 from mouse

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym(s):

C10, CCL6, MRP-1, SCYA6

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

recombinant

expressed in HEK 293 cells

tag

6-His tagged (C-terminus)

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 11.4 kDa (The predicted N-terminus is Gly22.)
observed mol wt 14 kDa by SDS-PAGE (reducing)

packaging

pkg of 10 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

P27784

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... CCL6(20305)

General description

Chemokine (C-C motif) ligand 6 (CCL6), a member of the CC chemokine family,[1] was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. CCL6 has only been identified in rodents. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages,[1] where it is strongly induced upon GM-CSF stimulation. Mouse CCL6 expression was also shown to be strongly induced by interleukin-4 (IL-4) in mouse macrophages and by cytokine IL-13 in mouse lung.[2] Mouse CCL6 is located on chromosome 11.[3] The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.[2]

Physical form

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP6251-10UG:

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The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines.
Berger MS
Dna and Cell Biology (1993)
The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling.
Ma B
Journal of Immunology (2004)
Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes.
Orlofsky A
Cell Regulation (1991)

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