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Key Documents

Safety Information

SRP6064

Sigma-Aldrich

UCHL1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):

PARK5, PGP9.5, UCHL1, Ubiquitin carboxyl-terminal esterase L1, Uch-L1

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About This Item

UNSPSC Code:
12352200

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

liquid

mol wt

24.8 kDa (223 aa)

packaging

pkg of 100 μg

NCBI accession no.

P09936

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... UCHL1(7345)

General description

PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson′s disease susceptibility. Recombinant PGP9.5 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

1 mg/mL solution in In 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM EDTA.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP6064-100UG:

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Certificates of Analysis (COA)

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Ewa Matuszczak et al.
Advances in medical sciences, 62(1), 83-86 (2017-02-15)
The study aims to determinate concentrations of ubiquitin C-terminal hydrolase 1 (UCHL1), which hydrolyzes amino acids from ubiquitin and cleave di-ubiquitins, in serum of children after thermal injury. 42 children scalded by hot water, managed at the Department of Pediatric
Vikram Puvenna et al.
PloS one, 9(5), e96296-e96296 (2014-05-09)
The impact of sub-concussive head hits (sub-CHIs) has been recently investigated in American football players, a population at risk for varying degrees of post-traumatic sequelae. Results show how sub-CHIs in athletes translate in serum as the appearance of reporters of
Roshan Kumar et al.
Scientific reports, 7, 44558-44558 (2017-03-17)
Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein

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