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Safety Information

SRP6027

Sigma-Aldrich

UbcH5b human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):

UbcH

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About This Item

CAS Number:
2026618-65-3
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

liquid

mol wt

17.0 kDa

packaging

pkg of 10 μg

concentration

~1.0 mg/mL

impurities

Endotoxin, tested

NCBI accession no.

P62837

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... UB2D2(7322)

General description

E2 ubiquitin conjugating enzyme (UbcH5b), also called as ubiquitin conjugating enzyme E2D2 (UBE2D2), belongs to the active class of E2 ubiquitin conjugating enzymes, which also includes UbcH5A and UbcH5C. UbcH5b structure contains four N-terminal α-helices followed by four-stranded antiparallel β-sheet.

Biochem/physiol Actions

E2 ubiquitin conjugating enzyme (UbcH5b) is a vital component of E3 complex SCFβ-TrCP and it plays an important role in phospho-IκBα ubiquitination. UbcH5b along with others members of active classes of E2 enzymes plays a vital role in degradation of many regulatory and abnormal proteins, including important human transcription factors, such as p53, nuclear factor-κB (NF-κB) and c-Fos.

Physical form

Supplied at a concentration of 1.0 mg/ml in 20 mM Tris-HCl, pH 7.5, containing 0.5 mM DTT.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP6027-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Solution structure of the ubiquitin-conjugating enzyme UbcH5B.
Houben K
Journal of Molecular Biology, 344(2), 513-526 (2004)
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes.
Kim DW
Proceedings of the National Academy of Sciences of the USA, 102(39), 14046-14051 (2005)

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