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Key Documents

Safety Information

SRP6016

Sigma-Aldrich

Endoglin murine

recombinant, expressed in Sf9 cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):

CD105, END, ENG, HHT1, ORW

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

recombinant

expressed in Sf9 cells

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

75-85 kDa

packaging

pkg of 10 μg

impurities

Endotoxin, tested

NCBI accession no.

Q63961

UniProt accession no.

Q63961

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... ENG(225297)

General description

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex and may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development . CD105 Mouse Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, polypeptide containing 581 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation, migrates at 75-85 kDa under reducing conditions in SDS-PAGE. Based on N-terminal sequence analysis, the primary structure of recombinant mature Endoglin starts at Glu 26. The CD105 is fused to a C-terminal His-tag (6xHis) and purified by proprietary chromatographic techniques.

Physical form

Lyophilized from sterile solution without additives

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP6016-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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