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Safety Information

SRP4809

Sigma-Aldrich

Calretinin from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

Synonym(s):

CR, Calb2, Calretinin, calbindin 2

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About This Item

UNSPSC Code:
12352202

biological source

mouse

recombinant

expressed in E. coli

Assay

≥90% (HPLC)
≥90% (SDS-PAGE)

form

solution

mol wt

~57 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

Q08331

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Calb2(12308)

General description

Calretinin is a Ca2+-binding protein. It belongs to the EF-hand family. This gene is upregulated in reactive mesothelial cells and in malignant mesothelioma.[1]
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.

Biochem/physiol Actions

Calretinin is widely distributed in the brain and might be responsible for neural protection. It regulates calcium signaling in neurons. Absence of calretinin in mice negatively affects long-term potentiation, motor coordination and Purkinje cell activity.[2][3]

Physical form

50 ml (100 μg/ml) in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, 20% Glycerol.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

JAN Code

SRP4809-5UG:

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Certificates of Analysis (COA)

Lot/Batch Number
60509
60609

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Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
Dong G, et al.
Journal of Neurochemistry, 123, 437-437 (2012)
Calretinin regulates Ca2+-dependent inactivation and facilitation of Ca(v)2.1 Ca2+ channels through a direct interaction with the a12.1 subunit.
Christel CJ, et al.
The Journal of Biological Chemistry, 287, 39766-39766 (2012)
Ayman Alzu'bi et al.
Frontiers in neuroanatomy, 14, 61-61 (2020-09-29)
Secretagogin (SCGN) which acts as a calcium signaling sensor, has previously been shown to be expressed by a substantial population of cortical GABAergic neurons at mid-gestation in humans but not in mice. The present study traced SCGN expression in cortical
Glyn Chidlow et al.
Brain structure & function, 221(8), 3903-3925 (2015-10-27)
Oxidative stress is implicated in various pathological conditions of the retina and optic nerve. Peroxiredoxins (Prdxs) comprise a recently characterized family of antioxidant enzymes. To date, little information exists regarding the distribution of Prdxs in the eye. Herein, we employed
Walter Blum et al.
Respiratory research, 16, 153-153 (2015-12-24)
The Ca(2+)-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin's likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus
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