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SRP2112

Sigma-Aldrich

TFIIB, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Synonym(s):

TF2B, TFIIB

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

biological source

human

recombinant

expressed in E. coli

Assay

≥70% (SDS-PAGE)

form

frozen liquid

mol wt

~61.2 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

400 μg/mL

color

clear colorless

NCBI accession no.

NM_001514

UniProt accession no.

Q00403

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... GTF2B(2959)

Biochem/physiol Actions

The transcription factor IIB (TFIIB) is an essential factor for transcription by RNA polymerase II. TFIIB has been shown to be required for selective binding of RNA polymerase II, TFIIF and TFIID-DNA complex, and for specifying the start site of transcription. Human TFIIB is a single, 35 kDa polypeptide, homologous to yeast factor, the product of the SUA7 gene.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP2112-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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General initiation factors for RNA polymerase II.
R C Conaway et al.
Annual review of biochemistry, 62, 161-190 (1993-01-01)
S Malik et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(21), 9553-9557 (1991-11-01)
Transcription factor TFIIB is a ubiquitous factor required for transcription initiation by RNA polymerase II. Previous studies have suggested that TFIIB serves as a bridge between the "TATA"-binding factor (TFIID) and RNA polymerase II during preinitiation complex assembly and, more
The general transcription factors of RNA polymerase II.
G Orphanides et al.
Genes & development, 10(21), 2657-2683 (1996-11-01)

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