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Safety Information

SRP0423

Sigma-Aldrich

Tankyrase 2 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

Synonym(s):

PARP5b, PARP5c, TNKS2, Tankyrase 2, poly(ADP-ribosyl)transferase 5b

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10 μG
¥76,300

¥76,300

List Price¥109,000Save 30%

Estimated to ship onMarch 17, 2025

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10 μG
¥76,300

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

¥76,300

List Price¥109,000Save 30%

Estimated to ship onMarch 17, 2025

Request a Bulk Order

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

80.5 kDa

packaging

pkg of 10 μg

NCBI accession no.

NM_025235

UniProt accession no.

Q9H2K2

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TNKS2(80351)

General description

TNKS2 (TRF1-interacting ankyrin-related ADP-ribose polymerase 2), also known as PARP5B/C, tanykyrase-2, or TNKL (GenBank Accession No. NM_025235) amino acids 667-1166 (end) with N-terminal GST-tag, MW=80.5 kDa, expressed in Sf9 cells via a Baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Physical form

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Cartagena Act

Cartagena Act Listed

JAN Code

SRP0423-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Brandoch D Cook et al.
Molecular and cellular biology, 22(1), 332-342 (2001-12-12)
Telomere maintenance is essential for the continuous growth of tumor cells. In most human tumors telomeres are maintained by telomerase, a specialized reverse transcriptase. Tankyrase 1, a human telomeric poly(ADP-ribose) polymerase (PARP), positively regulates telomere length through its interaction with
Natalie Sidorova et al.
Cell and tissue research, 323(1), 137-145 (2005-09-10)
Tankyrase, which functions at telomeres and other cellular compartments, is thought to be a positive regulator of telomerase; its isoenzyme tankyrase 2 has been cloned as a putative cancer antigen. This pilot immunohistochemical study was designed to examine whether tumors
P G Kaminker et al.
The Journal of biological chemistry, 276(38), 35891-35899 (2001-07-17)
Tankyrase (TANK1) is a human telomere-associated poly(ADP-ribose) polymerase (PARP) that binds the telomere-binding protein TRF1 and increases telomere length when overexpressed. Here we report characterization of a second human tankyrase, tankyrase 2 (TANK2), which can also interact with TRF1 but

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