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SRP0394

Sigma-Aldrich

EZH2/EED/SUZ12/RbAp48 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

48 kDa (RbBP5)
 51 kDa (EED)
 86 kDa (EZH2)
 87 kDa (SUZ12)

packaging

pkg of 50 μg

NCBI accession no.

NM_003797 (EED)
NM_004456 (EZH2)
NM_005610 (RbAP48)
NM_015355 (SUZ12)

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... EED(8726) , EZH2(2146) , RBBP4(5928) , SUZ12(23512)

General description

Complex of human EZH2 (GenBank Accession No. NM_004456), amino acids 2-end with N-terminal His-tag, MW= 86 kDa; human EED (GenBank Accession No. NM_003797) amino acids 2-end with N-terminal Flag-tag, MW= 51 kDa, human SUZ12 (GenBank Accession No. NM_015355) amino acids 2-end with N-terminal His-tag, MW = 87 kDa, and human RbAp48 (GenBank Accession No. NM_005610) amino acids 2-end with N-terminal His-tag, MW = 48 kDa, co-expressed in Baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Cartagena Act

Cartagena Act Listed

JAN Code

SRP0394-50UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rakotobe, D. et al.
Journal of Virology, 5, 32-32 (2008)
Sooryanarayana Varambally et al.
Science (New York, N.Y.), 322(5908), 1695-1699 (2008-11-15)
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain

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