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Safety Information

SRP0384

Sigma-Aldrich

MLL1/WDR5/Ash2L/RbBP5/DPY30 human

recombinant, expressed in E. coli, ≥83% (SDS-PAGE)

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥83% (SDS-PAGE)

form

aqueous solution

mol wt

12 kDa (DPY30)
 27 kDa (MLL1)
 35 kDa (WDR5)
 60 kDa (RbBP5)
 61 kDa (Ash2L)

packaging

pkg of 50 μg

NCBI accession no.

NM_001105214 (Ash2L)
NM_005057 (RbBP5)
NM_005933 (MLL1)
NM_017588 (WDR5)
NM_032574 (DPY30)

UniProt accession no.

 (P61964; Q9UBL3; Q9C005; Q15291)

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ASH2L(9070) , DPY30(84661) , MLL(4297) , RBBP5(5929) , WDR5(11091)

General description

MLL1/WARD complex of human MLL1 (GenBank Accession No. NM_005933) amino acids 3745-end with N-terminal His-tag, MW= 27 kDa, human WDR5 (GenBank Accession No. NM_017588), amino acids 22-end with N-terminal Flagtag, MW= 35 kDa, human Ash2L (GenBank Accession No. NM_001105214), amino acids 2-end with N-terminal His-tag, MW= 61 kDa, human RbBP5 (GenBank Accession No. NM_005057), amino acids 2-end with N-terminal His-tag, MW= 60 kDa, and human DPY30 (GenBank Accession No. NM_032574), amino acids 2-end with N-terminal His-tag, MW=12 kDa, individually expressed in an E. coli expression system.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

SRP0384-50UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Man Mohan et al.
Nature reviews. Cancer, 10(10), 721-728 (2010-09-17)
The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation of the elongation stage of transcription could
Anamika Patel et al.
The Journal of biological chemistry, 284(36), 24242-24256 (2009-06-27)
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute

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