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SRP0314

Sigma-Aldrich

FBXL11 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥15% (SDS-PAGE)

Synonym(s):

FBL7, FBXL11, JHDM1A, KDM2A, lysine (K)-specific demethylase 2A

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥15% (SDS-PAGE)

form

aqueous solution

mol wt

82 kDa

packaging

pkg of 20 μg

NCBI accession no.

NM_012308

UniProt accession no.

Q9Y2K7

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... KDM2A(22992)

General description

Human F-Box Protein 11 (FBXL11), also known as KDM2A, Ndy2, and JHDM1A GenBank Accession # NM_012308, a.a. 2-700 with N-terminal FLAGAvi- tag, MW = 82 kDa, expressed in Sf9 cells via a baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Analysis Note

Specific Activity: 0.01 pmole/min/μg using BPS Bioscience FBXL11 Homogeneous Assay Kit (Cat. No. 50611)

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP0314-20UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neil P Blackledge et al.
Molecular cell, 38(2), 179-190 (2010-04-27)
In higher eukaryotes, up to 70% of genes have high levels of nonmethylated cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units. These features, called CpG islands, were identified over 20 years ago, but there remains little mechanistic evidence
Yuji Tanaka et al.
The EMBO journal, 29(9), 1510-1522 (2010-04-10)
The rate-limiting step in ribosome biogenesis is the transcription of ribosomal RNA, which is controlled by environmental conditions. The JmjC enzyme KDM2A/JHDM1A/FbxL11 demethylates mono- and dimethylated Lys 36 of histone H3, but its function is unclear. Here, we show that
David Frescas et al.
Cell cycle (Georgetown, Tex.), 7(22), 3539-3547 (2008-11-13)
Heterochromatin plays an essential role in the preservation of epigenetic information, the transcriptional repression of repetitive DNA elements and inactive genes, and the proper segregation of chromosomes during mitosis. Here we identify KDM2A, a JmjC-domain containing histone demethylase, as a

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