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SML3984

Sigma-Aldrich

Insulin sensitizer, C59

new

≥98% (HPLC)

Synonym(s):

N-(4,5-Dichloro-2-pyridinyl)tricyclo[3.3.1.13,7]decane-1-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C16H18Cl2N2O
CAS Number:
2761446-81-3
Molecular Weight:
325.23
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Biochem/physiol Actions

Orally available potentiator of insulin action that significantly improves glucose tolerance in DIO mice; restores insulin-stimulated GLUT4 translocation.



Insulin sensitizer C59 is an orally available potentiator of insulin action that significantly improves glucose tolerance in DIO mice. Insulin sensitizer C59 restores insulin-stimulated GLUT4 translocation without targeting PPARγ. It acts through interaction with Unc119 proteins. C59 lowers fasting blood glucose and plasma insulin concentrations in in DIO mice.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3984-5MG:
SML3984-BULK:
SML3984-25MG:
SML3984-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Terry C Yin et al.
Cell chemical biology, 30(8), 933-942 (2023-07-16)
Insulin resistance (IR) is the root cause of type II diabetes, yet no safe treatment is available to address it. Using a high throughput compatible assay that measures real-time translocation of the glucose transporter glucose transporter 4 (GLUT4), we identified

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