SML3963

DPPA-1 acetate

≥95% (HPLC)

• Synonym(s): (D)-APP acetate, (D)-NYSKPTDRQYHF acetate, (D)-PPA 1 acetate, (D)-PPA acetate, (D)-PPA-1 acetate, (D)-PPA1 acetate, Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe (all D-amino acids) acetate, D PD-1/PD-L1 interaction Antagonist-1 acetate, D-APP acetate, D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe, D-PPA 1 acetate, D-PPA acetate, D-type APP acetate, D-type anti-PD-L1 peptide acetate, DPPA 1 acetate, DPPA-1 acetate, DPPA1 acetate, NYSKPTDRQYHF (all D-amino acids) acetate, PD-L1-targeting D-peptide acetate
• Empirical Formula (Hill Notation): C₇₀H₉₈N₂₀O₂₁ · xC₂H₄O₂
• Molecular Weight: 1555.65 (free base basis)
• UNSPSC Code: 51111800
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) interaction antagonist/blocker with anti-cancer efficacy in vitro and in vivo.



DPPA-1 is a programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1) interaction antagonist/blocker that targets PD-L1 via direct affinity binding (KD = 0.51 μM). DPPA-1 effectively blocks soluble Fc-labeled human PD-L1 from binding cell surface PD-1 in vitro and shows anti-tumor efficacy among CT26 tumor-bearing mice in vivo (2 mg/kg via daily i.p.).

Citation

Hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable