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Safety Information

SML3816

Sigma-Aldrich

Cynandione A

≥98% (HPLC)

Synonym(s):

1-(2′-Acetyl-2,3′,6,6′-tetrahydroxy[1,1′-biphenyl]-3-yl)ethanone

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About This Item

Empirical Formula (Hill Notation):
C16H14O6
CAS Number:
168706-29-4
Molecular Weight:
302.28
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

OC1=C(C(O)=CC=C1C(C)=O)C2=C(C=CC(O)=C2C(C)=O)O

InChI

1S/C16H14O6/c1-7(17)9-3-4-12(21)15(16(9)22)14-11(20)6-5-10(19)13(14)8(2)18/h3-6,19-22H,1-2H3

Biochem/physiol Actions

Cynandione A is a primary bioactive component of medical plant Cynanchum wilfordii that exhibit neuroprotective and hepatoprotective effects. Cynandione A induces SIRT1 (silent information regulator 2 homolog 1) nuclear translocation through the PKA signaling pathway resulting in beiging (differentiation) in 3T3-L1 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3816-5MG:
SML3816-BULK:
SML3816-25MG:
SML3816-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000269649
0000269648

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Cynandione A inhibits lipopolysaccharide-induced cell adhesion via suppression of the protein expression of VCAM?1 in human endothelial cells
International Journal of Molecular Medicine, 41(3), 1756-1764 (2018)
Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells
European Journal of Pharmacology, 909, 174382-174382 (2021)
Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
Molecules (Basel), 26(23), 7065-7065 (2021)

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