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Safety Information

SML3761

Sigma-Aldrich

BRD7586

≥98% (HPLC)

Synonym(s):

3-[(4-Chlorophenyl)sulfonyl]-N-[4-(4-pyridinyl)-2-thiazolyl]propanamide

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About This Item

Empirical Formula (Hill Notation):
C17H14ClN3O3S2
Molecular Weight:
407.89
MDL number:
MFCD07191127
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

[S](=O)(=O)(CCC(=O)Nc2[s]cc(n2)c3ccncc3)c1ccc(cc1)Cl

InChI

1S/C17H14ClN3O3S2/c18-13-1-3-14(4-2-13)26(23,24)10-7-16(22)21-17-20-15(11-25-17)12-5-8-19-9-6-12/h1-6,8-9,11H,7,10H2,(H,20,21,22)

InChI key

MLSIIIMAQNQEOV-UHFFFAOYSA-N

Biochem/physiol Actions

BRD7586 is a cell-permeable, and potent anti-CRISPR agent. BRD7586is a potent and selective inhibitor of SpCas9. It potently inhibits SpCas9 in both HEK293T and U2OS.eGFP.PEST cells without altering its expression, or induction of cytotoxicity. BRD7586 enhanced the specificity of SpCas9. BRD7586 inhibits genome editing at diverse endogenous loci. It is twofold more potent than BRD0539.
Cell-permeable, and potent anti-CRISPR agent; potent and selective inhibitor of SpCas9

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3761-25MG:
SML3761-5MG:
SML3761-VAR:
SML3761-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000301232
0000301233
0000301233
0000301232
0000273048

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A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules
Nature Cell Biology, 24(12), 1766-1775 (2022)

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