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Safety Information

SML3553

Sigma-Aldrich

STF-1084

≥98% (HPLC)

Synonym(s):

ENPP1 inhibitor Compound 15, P-​[2-​[1-​(6,​7-​dimethoxy-​4-​quinazolinyl)​-​4-​piperidinyl]​ethyl]​-phosphonic acid

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About This Item

Empirical Formula (Hill Notation):
C17H24N3O5P
CAS Number:
2298390-71-1
Molecular Weight:
381.36
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=P(O)(O)CCC(CC1)CCN1C2=NC=NC3=C2C=C(OC)C(OC)=C3

Biochem/physiol Actions

STF-1084 (ENPP1 inhibitor Compound 15) Is a cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 (ectonucleotide pyrophosphatase phosphodiesterase 1) that inhibit degradation of extracellular cGAMP under physiological conditions. STF-1084 had no effect on intracellular cGAMP. STF-1084 synergized with IR to significantly delay tumor progression in three triple-negative breast cancer cell lines 4T1-luc mice model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3553-VAR:
SML3553-25MG:
SML3553-BULK:
SML3553-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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32726585
Cell Chemical Biology, 27, 1347-1358 (2020)
Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity
Nature cancer, 1, 184-196 (2020)

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