Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML3505

Sigma-Aldrich

KP1339

≥98% (elemental analysis)

Synonym(s):

BOLD-100 without cesium, FFC14A sodium salt, IT-139, KP1019 sodium salt, IndazolH [trans-RuCl(4)-(Indazol)(2)] sodium salt, NKP1339, trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] sodium salt

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C14H12Cl4N4NaRu
CAS Number:
197723-00-5
Molecular Weight:
502.14
MDL number:
MFCD25976832
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (elemental analysis)

form

powder

color

, white to very dark grey

solubility

H2O: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

Cl[Ru-](Cl)(Cl)Cl.C1(C=CC=C2)=C2NN=C1.C3(C=CC=C4)=C4NN=C3.[Na+]

InChI

1S/2C7H6N2.4ClH.Na.Ru/c2*1-2-4-7-6(3-1)5-8-9-7;;;;;;/h2*1-5H,(H,8,9);4*1H;;/q;;;;;;+1;+3/p-4

InChI key

WVVOCRYXBTVDRN-UHFFFAOYSA-J

Biochem/physiol Actions

KP1339 (KP1019 sodium) is a ruthenium-indazole complex-based anticancer agent that induces pronounced apoptosis in sensetive cancer cells (Capan1/HCT116/SW480/KB-3-1 IC50 by MTT assay = 44/50/145/170 µM) via ER homeostasis disruption and caspase 8 activation due to depletion of key cellular chaperones, including BiP/GRP78/HSPA5, in combination with enhanced protein damage. When administered in vivo, KP1339 exhibits anti-tumor efficacy in the murine SA-1 fibrosarcoma model (10.5, 21.0, 42.0 mg/150 µL/kg i.v.).
Ruthenium-indazole complex-based anticancer agent in cultures and in vivo via ER homeostasis disruption by depleting chaperones, including BiP/GRP78/HSPA5.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3505-BULK:
SML3505-VAR:
SML3505-25MG:
SML3505-5MG:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000197313

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum
Angewandte Chemie (International ed. in English), 60, 5063-5068 (2021)
The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo
Anticancer Research, 30, 2055-2063 (2010)
Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis
Cancer Letters, 404, 79-88 (2017)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service