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SML3243

Sigma-Aldrich

NA-11

≥98% (HPLC)

Synonym(s):

N-(2-(2-(5-hydroxypent-1-yn-1-yl)phenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide

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5 MG
¥16,000
25 MG
¥64,200

¥16,000

Estimated to ship onJune 01, 2025

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5 MG
¥16,000
25 MG
¥64,200

About This Item

Empirical Formula (Hill Notation):
C24H23N3O3
Molecular Weight:
401.46
UNSPSC Code:
12352107
NACRES:
NA.77

¥16,000

Estimated to ship onJune 01, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OCCCC#CC1=CC=CC=C1C2=NN3C(COC(C=C(NC(C)=O)C=C4)=C4C3)=C2

InChI

1S/C24H23N3O3/c1-17(29)25-20-11-10-19-15-27-21(16-30-24(19)13-20)14-23(26-27)22-9-5-4-8-18(22)7-3-2-6-12-28/h4-5,8-11,13-14,28H,2,6,12,15-16H2,1H3,(H,25,29)

InChI key

VVMOXIHBNMUNFJ-UHFFFAOYSA-N

Biochem/physiol Actions

NA-11 is a potent and selective activator of PFKL (phosphofructokinase-1 liver type) that suppress excessive NOX2-dependent oxidative burst and neutrophil cell death (NETosis). NA-11 decreases neutrophiles efficiency to kill bacteria. It prevents neutrophil-induced tissue damage.
potent and selective activator of PFKL (phosphofructokinase-1 liver type) that suppress excessive NOX2-dependent oxidative burst

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3243-BULK:
SML3243-25MG:
SML3243-5MG:
SML3243-VAR:

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Neri Amara et al.
Cell, 184(17), 4480-4494 (2021-07-29)
In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen species for killing invading pathogens. However, excessive NOX2 activity can exacerbate inflammation, as in acute respiratory distress syndrome (ARDS).

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