Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML2981

Sigma-Aldrich

EN219

≥98% (HPLC)

Synonym(s):

1-(3,5-bis(4-Bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone, 3,5-bis(4-Bromophenyl)-1-(chloroacetyl)-4,5-dihydro-1H-pyrazole

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
¥16,830
25 MG
¥67,490

¥16,830

Estimated to ship onApril 18, 2025

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
¥16,830
25 MG
¥67,490

About This Item

Empirical Formula (Hill Notation):
C17H13Br2ClN2O
CAS Number:
380351-29-1
Molecular Weight:
456.56
MDL number:
MFCD02989881
UNSPSC Code:
12352200
NACRES:
NA.77

¥16,830

Estimated to ship onApril 18, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Brc1ccc(cc1)C2N(NC(=C2)c3ccc(cc3)Br)C(=O)CCl

InChI key

PREWPJFURADJST-UHFFFAOYSA-N

Biochem/physiol Actions

EN219 is a cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 is shown to covalently interact with RNF114-C8 (IC50 = 470 nM), TUBB1-C201, HSPD1-C442, and HIST1H3A-C97. EN219 is a recruiter of the E3 ubiquitin ligase RNF114 that can be utilized for PROTAC applications.
cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2981-VAR:
SML2981-5MG:
SML2981-BULK:
SML2981-25MG:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000119922
0000119923
0000112133

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service