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SML2927

Sigma-Aldrich

H3B-193

≥98% (HPLC)

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5 MG
¥13,600
25 MG
¥54,900

¥13,600

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5 MG
¥13,600
25 MG
¥54,900

About This Item

Empirical Formula (Hill Notation):
C19H23FN4O2S
CAS Number:
2642171-68-2
Molecular Weight:
390.47
UNSPSC Code:
12352200
NACRES:
NA.77

¥13,600

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Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=NC(C)=CS1)C2CCN(C(N(CC3=CC=C(F)C=C3)C)=O)CC2

InChI

1S/C19H23FN4O2S/c1-13-12-27-18(21-13)22-17(25)15-7-9-24(10-8-15)19(26)23(2)11-14-3-5-16(20)6-4-14/h3-6,12,15H,7-11H2,1-2H3,(H,21,22,25)

InChI key

FYQIXROHNRZVMM-UHFFFAOYSA-N

Biochem/physiol Actions

H3B-193 is a cell penetrant, potent and selective allosteric inhibitor of the carbamoyl phosphate synthetase 1 (CPS1) that blocks ATP hydrolysis in the first step of carbamoyl phosphate synthesis
cell penetrant, potent and selective allosteric inhibitor of the carbamoyl phosphate synthetase 1 (CPS1)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2927-BULK:
SML2927-5MG:
SML2927-VAR:
SML2927-25MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000123819
0000123820
0000119927

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Shihua Yao et al.
Cell chemical biology, 27(3), 259-268 (2020-02-06)
Carbamoyl phosphate synthetase 1 (CPS1) catalyzes the first step in the ammonia-detoxifying urea cycle, converting ammonia to carbamoyl phosphate under physiologic conditions. In cancer, CPS1 overexpression supports pyrimidine synthesis to promote tumor growth in some cancer types, while in others

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