Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML2924

Sigma-Aldrich

AZ1729

≥98% (HPLC)

Synonym(s):

AZ 1729, N-[3-(2-carbamimidamido-4-methyl-1,3-thiazol-5-yl)phenyl]-4-fluorobenzamide

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
¥17,430
25 MG
¥56,360

¥17,430

Check Cart for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
¥17,430
25 MG
¥56,360

About This Item

Empirical Formula (Hill Notation):
C18H16FN5OS
CAS Number:
2016864-46-1
Molecular Weight:
369.42
UNSPSC Code:
12352200
NACRES:
NA.77

¥17,430

Check Cart for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

Fc1ccc(cc1)C(=O)Nc2cc(ccc2)c3[s]c(nc3C)NC(=N)N

InChI

1S/C18H16FN5OS/c1-10-15(26-18(22-10)24-17(20)21)12-3-2-4-14(9-12)23-16(25)11-5-7-13(19)8-6-11/h2-9H,1H3,(H,23,25)(H4,20,21,22,24)

InChI key

HULFYSCAJVTAAR-UHFFFAOYSA-N

Biochem/physiol Actions

AZ1729 is a short chain fatty acid receptor FFA2 (GPR43) regulator that acts as a direct allosteric agonist and as a positive allosteric modulator (PAM). AZ1729 selectively enhances Gi-mediated signaling (Gi-biased ligand), but not at those transduced by Gq/G11 pathway.
FFA2 (GPR43) regulator that acts as a direct allosteric agonist and as a positive allosteric modulator (PAM); Gi-biased ligand

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2924-VAR:
SML2924-5MG:
SML2924-25MG:
SML2924-BULK:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Eugenia Sergeev et al.
Scientific reports, 7(1), 13741-13741 (2017-10-25)
Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates. A major challenge in studying this receptor is that the mouse ortholog
Daniele Bolognini et al.
The Journal of biological chemistry, 291(36), 18915-18931 (2016-07-08)
The short chain fatty acid receptor FFA2 is able to stimulate signaling via both Gi- and Gq/G11-promoted pathways. These pathways are believed to control distinct physiological end points but FFA2 receptor ligands appropriate to test this hypothesis have been lacking.
Simon Lind et al.
Biochimica et biophysica acta. Molecular cell research, 1867(6), 118689-118689 (2020-02-25)
The non-activating allosteric modulator AZ1729, specific for free fatty acid receptor 2 (FFAR2), transfers the orthosteric FFAR2 agonists propionate and the P2Y2R specific agonist ATP into activating ligands that trigger an assembly of the neutrophil superoxide generating NADPH-oxidase. The homologous

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service