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Safety Information

SML2892

Sigma-Aldrich

LY2584702 tosylate

≥98% (HPLC)

Synonym(s):

4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine, 4-methylbenzenesulfonate (1:1), LY 2584702 tosylate, LY 2779964, LY-2584702 tosylate, LY-2779964, LY2779964, LYS6K2 tosylate

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5 MG
¥10,200
25 MG
¥40,970

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5 MG
¥10,200
25 MG
¥40,970

About This Item

Empirical Formula (Hill Notation):
C21H19F4N7 · C7H8O3S
CAS Number:
1082949-68-5
Molecular Weight:
617.62
MDL number:
MFCD29054739
UNSPSC Code:
12352200
NACRES:
NA.77

¥10,200

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c2c(ccc(c2)c3nc([n](c3)C)C4CCN(CC4)c5ncnc6n[nH]cc65)F.[S](=O)(=O)(O)c1ccc(cc1)C

InChI

1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10)

InChI key

HDYUXDNMHBQKAU-UHFFFAOYSA-N

Biochem/physiol Actions

LY2584702 is an orally active, ATP-competitive, potent and selective ribosomal protein S6 kinase (p70 S6 kinase, p70S6K, S6K1) inhibitor (IC50 = 4 nM; selective over 83 other kinases and 45 cell surface markers). LY2584702 inhibits HCT116 cellular S6 phosphorylation (IC50 0.1-0.24 μM) and shows anti-tumor efficacy in U87MG glioblastoma and HCT116 colon carcinoma xenograft models in vivo (2.5 mg/kg bid. po.).
Orally active, ATP-competitive, potent and selective ribosomal protein S6 kinase (p70 S6 kinase, p70S6K, S6K1) inhibitor with in vivo anti-tumor efficacy.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2892-5MG:
SML2892-VAR:
SML2892-BULK:
SML2892-25MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000110764
0000110765
0000102945

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Ming-Zhao Gao et al.
Acta pharmacologica Sinica, 40(2), 268-278 (2018-05-20)
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Victoria E B Hipolito et al.
PLoS biology, 17(12), e3000535-e3000535 (2019-12-05)
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Elizabeth K K Glennon et al.
Cell reports, 26(12), 3391-3399 (2019-03-21)
Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of
Honyin Chiu et al.
Journal of immunology (Baltimore, Md. : 1950), 202(2), 579-590 (2018-12-12)
During an adaptive immune response, activated mature B cells give rise to Ab-secreting plasma cells to fight infection. B cells undergo Ab class switching to produce different classes of Abs with varying effector functions. The mammalian/mechanistic target of rapamycin (mTOR)
Valentina Romeo et al.
Journal of immunology (Baltimore, Md. : 1950), 203(1), 137-147 (2019-05-17)
PI3K is one of the most frequently mutated genes in cancers and has been the target of numerous anticancer therapies. With the additional development of therapeutics that mobilize the immune system, such as Abs with effector functions, bispecific Abs, and
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